Description
Ketanserin tartrate is the tartrate salt of ketanserin, which is a potent and selective serotonin (5-HT) receptor antagonist. It is selective for 5-HT2 with IC50 value of 6.3 nM and Ki value of 2.1 nM, but has no activity at 5-HT1 receptors. It is used in nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. It could prevent some diseases ranging from cancer to ischemic injury. It induces dose-dependent inhibition of contractile responses to 5-HT in isolated canine basilar, rat caudal artery, carotid, gastrosplenic arteries, coronary and so on. It reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction. It significantly decreases blood pressure variability (BPV) and hypertensive organ damage in spontaneously hypertensive rats. It may be used to treat hypertension in early-onset preeclampsia